These grains are completely masqueradecomfort cell nuclei. In some descriptions of altace pills of the disease, a histological structure is given corresponding to get ramipril planus (hyperkeratosis, hypergranulosis, uneven acanthosis, cellular infiltrate in the dermoepidermal zone).
Immunofluorescent method revealed granular deposits of IgM in the area of the dermoepidermal junction. Electron microscopy reveals keratinocyte damage, intercellular edema, retraction (retraction) of desmosomes, rupture of the basement membrane, and dermal melanophagocytosis. There are many melanophages in the dermis, consisting of accumulations of melanosomes enclosed in lysosomal membranes. The diagnosis is based on anamnestic, clinical and histological data.
Differentiate with hemochromatosis, fixed drug erythema, pigmented form of lichen planus, mastocytosis, patchy amyloidosis, focal scleroderma, syphilis. Current and forecast. The disease can begin suddenly with the appearance of multiple rashes or develop gradually with the appearance of one or more elements. The course is long, sometimes spontaneous resolution of foci is noted in terms of 2-3 months to 1.5-2 years. The general condition is not violated. Pathology from the internal organs is not detected.
Antibiotics, corticosteroids, sulfones, antimalarials, nonsteroidal antiphlogistics are ineffective. It is possible to buy altace online after sanitation of foci of chronic infection. Assign bleaching creams with hydroquinone, skinoren. There are good results in treatment with the use of narrow-band UVI. A clinical observation with this nosological form is presented.
At the age of 25, foci of not pronounced hyperpigmentation suddenly appeared. I went to the dermatologist for the first time after 3 months. On examination, foci of brownish-bluish coloration were localized in the supraclavicular region on the left, the upper third of the left shoulder and the lower third of the thigh. A differential diagnosis was made between persistent dyschromic erythema and scleroderma. Histological examination showed epidermis with slight hyperkeratosis and acanthosis. In the upper layers of the dermis, there is a moderately pronounced perivascular infiltration mainly by lymphocytes and an accumulation of melanin.
Based on the nature of the skin lesion and the results of pathological examination, persistent dyschromic erythema was diagnosed. External therapy with Skinoren was prescribed. After 3 months, the lesions resolved. In some cases, no nosological form of melanin melanosis can be established, despite a comprehensive examination of ramipril pills with a histological examination. The following clinical observation is presented. Widespread melanin melanosis of unknown origin in a 24-year-old patient.